Lung-gut axis of microbiome alterations following co-exposure to ultrafine carbon black and ozone.

ABSTRACT:

Background

Microbial dysbiosis is a potential mediator of air pollution-induced adverse outcomes. However, a systemic comparison of the lung and gut microbiome alterations and lung-gut axis following air pollution exposure is scant. In this study, we exposed male C57BL/6J mice to inhaled air, CB (10 mg/m³), O₃ (2 ppm) or CB + O₃ mixture for 3 h/day for either one day or four consecutive days and were euthanized 24 h post last exposure. The lung and gut microbiome were quantified by 16 s sequencing.

Results

Multiple CB + O₃ exposures induced an increase in the lung inflammatory cells (neutrophils, eosinophils and B lymphocytes), reduced absolute bacterial load in the lungs and increased load in the gut. CB + O₃ exposure w

SUBMITTER: Mazumder MHH 

PROVIDER: S-EPMC10122302 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature