Diverging patterns of plasticity in the nucleus basalis of Meynert in early- and late-onset blindness.

ABSTRACT: Plasticity in the brain is impacted by an individual's age at the onset of the blindness. However, what drives the varying degrees of plasticity remains largely unclear. One possible explanation attributes the mechanisms for the differing levels of plasticity to the cholinergic signals originating in the nucleus basalis of Meynert. This explanation is based on the fact that the nucleus basalis of Meynert can modulate cortical processes such as plasticity and sensory encoding through its widespread cholinergic projections. Nevertheless, there is no direct evidence indicating that the nucleus basalis of Meynert undergoes plastic changes following blindness. Therefore, using multiparametric magnetic resonance imaging, we examined if the structural and functional properties of the nucleus basa

SUBMITTER: Bang JW 

PROVIDER: S-EPMC10123399 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature