Socioeconomic Deprivation, Genetic Risk, and Incident Dementia.

ABSTRACT:

Introduction

Socioeconomic factors and genetic predisposition are established risk factors for dementia. It remains unclear whether associations of socioeconomic deprivation with dementia incidence are modified by genetic risk.

Methods

Participants in the UK Biobank aged ≥60 years and of European ancestry without dementia at baseline (2006-2010) were eligible for the analysis, with the main exposures area-level deprivation based on the Townsend Deprivation Index and individual-level socioeconomic deprivation based on car and home ownership, housing type and income, and polygenic risk of dementia. Dementia was ascertained in hospital and death records. Analysis was conducted in 2021.

Results

In this cohort study, 196,368 participants (mean [SD] age=64.1 [2.9] years, 52

SUBMITTER: Klee M 

PROVIDER: S-EPMC10126314 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature