Potential contribution of Helicobacter pylori proteins in the pathogenesis of type 1 gastric neuroendocrine tumor and urticaria. In silico approach.

ABSTRACT:

Background

Helicobacter pylori has been linked to several diseases such as chronic urticaria, gastritis, and type 1 gastric neuroendocrine tumors (type 1 gNET). Although these diseases seem to have different mechanisms, their relationship with H. pylori suggests a common inflammatory pathway.

Objective

To identify potential cross-reactive antigens between H. pylori and humans involved in chronic urticaria and type 1 gNET.

Methods

Alignment was carried out among human proteins associated with urticaria (9 proteins), type 1 gNET (32 proteins), and H. pylori proteome. We performed pairwise alignment among the human and H. pylori antigens with PSI-BLAST. Modeling based on homology was done with the Swiss model server and epitope prediction with the Ellipro server. Epitope

SUBMITTER: Sanchez Caraballo A 

PROVIDER: S-EPMC10128923 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature