Helicobacter pylori infection dysregulates gastric proteome

ABSTRACT: The purpose of the study was to define gastric cell-specific proteomic changes, induced by H. pylori oncogenic strains, that are critical for initiation of the gastric carcinogenic cascade. Gastric cell scrapings were harvested from H. pylori-infected and uninfected animals for quantitative proteomic analyses using isobaric tags for relative and absolute quantitation (iTRAQ). Canonical and disease pathway mapping using Ingenuity Pathway Analysis (IPA) identified significantly altered inflammatory and cancer-signaling pathways that included Rab/Ras signaling proteins.

INSTRUMENT(S):

ORGANISM(S): Meriones Unguiculatus

TISSUE(S): Gastric Epithelium, Epithelial Cell

DISEASE(S): Gastric Adenocarcinoma

SUBMITTER: Kristie Lindsey Rose  

LAB HEAD: Kristie Lindsey Rose

PROVIDER: PXD009583 | Pride | 2018-11-23

REPOSITORIES: Pride