The More Extensive the Spread through Air Spaces, the Worse the Prognosis Is: Semi-Quantitative Evaluation of Spread through Air Spaces in Pulmonary Adenocarcinomas.

ABSTRACT:

Introduction

The extent of spread through air spaces (STAS) is less investigated among patients with lung adenocarcinoma who underwent sublobar resection. Therefore, we aimed to evaluate the extent of STAS semi-quantitatively, to assess its prognostic impact on overall survival (OS) and recurrence-free survival (RFS), and to investigate the reproducibility of this assessment.

Methods

The number of tumour cell clusters and single tumour cells within air spaces was recorded in three different most prominent areas (200x field of view). The extent of STAS was categorized into three groups, and the presence of free tumour cluster (FTC) was recorded.

Results

Sixty-one patients were included. Recurrence was more frequent with higher grade (p = 0.003), presence of lymphovascu

SUBMITTER: Zombori-Toth N 

PROVIDER: S-EPMC10129026 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature