Genetic associations between circulating metabolic biomarkers and lung cancer in East Asians and Europeans.

ABSTRACT:

Background

Metabolic biomarkers are reported to be associated with the risk of lung cancer (LC). However, the observed associations from epidemiological studies are either inconsistent or inconclusive.

Methods

The genetic summary data of high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), total cholesterol (TC), triglyceride (TG), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c) and those of the LC and its histological subtypes were retrieved from previous GWASs. We performed two-sample Mendelian randomization (MR) and multivariable MR analyses to examine the associations between genetically predicted metabolic biomarkers and LC in East Asians and Europeans.

Results

In East Asians, the inverse-variance weighted (IVW) met

SUBMITTER: Liu K 

PROVIDER: S-EPMC10131379 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature