ClC-3 regulates the excitability of nociceptive neurons and is involved in inflammatory processes within the spinal sensory pathway.

ABSTRACT: ClC-3 Cl^-/H⁺ exchangers are expressed in multiple endosomal compartments and likely modify intra-endosomal pH and [Cl^-] via the stoichiometrically coupled exchange of two Cl^- ions and one H⁺. We studied pain perception in Clcn3^-/- mice and found that ClC-3 not only modifies the electrical activity of peripheral nociceptors but is also involved in inflammatory processes in the spinal cord. We demonstrate that ClC-3 regulates the number of Na _v and K _v ion channels in the plasma membrane of dorsal root ganglion (DRG) neurons and that these changes impair the age-dependent decline in excitability of sensory neurons. To distinguish the role of ClC-3 in Cl^-

SUBMITTER: Sierra-Marquez J 

PROVIDER: S-EPMC10134905 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature