Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections.

ABSTRACT:

Background

Interventions to reduce sexually transmitted infections (STIs) among men who have sex with men (MSM) are needed.

Methods

We conducted an open-label, randomized study involving MSM and transgender women who were taking preexposure prophylaxis (PrEP) against human immunodeficiency virus (HIV) infection (PrEP cohort) or living with HIV infection (persons living with HIV infection [PLWH] cohort) and who had had Neisseria gonorrhoeae (gonorrhea), Chlamydia trachomatis (chlamydia), or syphilis in the past year. Participants were randomly assigned in a 2:1 ratio to take 200 mg of doxycycline within 72 hours after condomless sex (doxycycline postexposure prophylaxis) or receive standard care without doxycycline. STI testing was performed quarterly. The prima

SUBMITTER: Luetkemeyer AF 

PROVIDER: S-EPMC10140182 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature