Regioselective Reaction of 2-Indolylmethanols with Enamides.

ABSTRACT: A highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl₃ as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformation represents the efficient way to introduce biologically important indoles and enamides skeleton into structurally complex hybrids.

SUBMITTER: Tian Y 

PROVIDER: S-EPMC10140953 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature