Genomic Insights into Bacterial Resistance to Proline-Rich Antimicrobial Peptide Bac7.

ABSTRACT: Proline-rich antimicrobial peptides (PrAMPs) having a potent antimicrobial activity and a modest toxicity toward mammalian cells attract much attention as new templates for the development of antibiotic drugs. However, a comprehensive understanding of mechanisms of bacterial resistance development to PrAMPs is necessary before their clinical application. In this study, development of the resistance to the proline-rich bovine cathelicidin Bac7_1-22 derivative was characterized in the multidrug-resistant Escherichia coli clinical isolate causing the urinary tract infection. Three Bac7_1-22-resistant strains with ≥16-fold increase in minimal inhibitory concentrations (MICs) were selected by serially passaging after four-week experimental evolution. It was shown that

SUBMITTER: Panteleev PV 

PROVIDER: S-EPMC10145973 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature