MCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure.

ABSTRACT:

Background

Mitochondrial calcium (_mCa²⁺) uptake through the mitochondrial calcium uniporter channel (mtCU) stimulates metabolism to meet acute increases in cardiac energy demand. However, excessive _mCa²⁺ uptake during stress, as in ischemia-reperfusion, initiates permeability transition and cell death. Despite these often-reported acute physiological and pathological effects, a major unresolved controversy is whether mtCU-dependent _mCa²⁺ uptake and long-term elevation of cardiomyocyte _mCa²⁺ contributes to the heart's adaptation during sustained increases in workload.

Objective

We tested the hypothesis that mtCU-dependent _mCa²⁺ uptake contributes to cardiac adaptation

SUBMITTER: Garbincius JF 

PROVIDER: S-EPMC10153142 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature