Diminished Auditory Cortex Dynamic Range and its Clinical Correlates in First Episode Psychosis.

ABSTRACT:

Background and hypothesis

There is growing appreciation for the contribution of sensory disruptions to disease morbidity in psychosis. The present study examined auditory cortex (AC) dynamic range: the scaling of neurophysiological responses to stimulus intensity, among individuals with a schizophrenia spectrum illness (FESz) and its relationship to clinical outcomes at disease onset.

Study design

Magnetoencephalography (MEG) was recorded from 35 FESz and 40 healthy controls (HC) during binaural presentation of tones at three intensities (75 dB, 80 dB, and 85 dB). MRIs were obtained to enhance cortical localization of MEG sensor-level activity. All participants completed the MATRICS cognitive battery (MCCB) and Global Functioning: Role and Social scales (GFR/GFS). Patients w

SUBMITTER: Sklar AL 

PROVIDER: S-EPMC10154701 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature