Dataset Information

Environmental Exposure to Emerging Alternatives of Per- and Polyfluoroalkyl Substances and Polycystic Ovarian Syndrome in Women Diagnosed with Infertility: A Mixture Analysis.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFAS) have been previously linked to polycystic ovarian syndrome (PCOS), but only a few legacy PFAS were examined.

Objectives

This study aimed to explore this association with a variety of PFAS, including legacy, branched-chain isomers, and emerging alternatives, as well as a PFAS mixture.

Methods

From 2014 to 2016, we conducted a multicenter, hospital-based case-control study on environmental endocrine disruptors and infertility in China. Three hundred sixty-six women with PCOS-related infertility and 577 control participants without PCOS were included in the current analysis. Twenty-three PFAS, including 3 emerging PFAS alternatives, 6 linear and branched PFAS isomers, 6 short-chain PFAS, and 8 legacy PFAS, were quantified in the plasma. Logistic regression and two multipollutant models [quantile-based g-computation (QGC) and Bayesian kernel machine regression (BKMR) methods] were used to assess the association of individual PFAS and PFAS mixture with PCOS, as well as the potential interactions among the congeners.

Results

After adjusting for potential confounders, Each 1-standard deviation higher difference in ln-transformed 6:2 chlorinated perfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) and hexafluoropropylene oxide dimer acid (HFPO-DA) level was significantly associated with a 29% (95% CI: 1.11, 1.52) and 39% (95% CI:1.16, 1.68) higher odds of PCOS, respectively. Meanwhile, branched isomers of perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) (i.e., br-PFHxS, n-PFOS, 1m-PFOS, Σ3,4,5m-PFOS), short-chain PFAS (i.e., PFPeS and PFHxA) and other legacy PFAS [i.e., total concentrations of PFOS (T-PFOS), and perfluorododecanoic acid (PFDoA)] were significantly associated with increased odds of PCOS. The PFAS mixture was positively related to PCOS in the BKMR model. A similar trend was observed in QGC model, a ln-unit increase in the PFAS mixture was associated with a 20% increased risk of PCOS [adjusted odds ratio (aOR)=1.20 (95% CI: 1.06, 1.37)]. After controlling for other PFAS homologs, 6:2 Cl-PFESA, HFPO-DA, Σ3,4,5m-PFOS, and PFDoA were the major contributors based on the QGC and BKMR models. The associations were more pronounced in overweight/obese women.

Conclusions

In this group of women, environmental exposure to a PFAS mixture was associated with an elevated odds of PCOS, with 6:2 Cl-PFESA, HFPO-DA, Σ3,4,5m-PFOS, and PFDoA being the major contributors, especially in overweight/obese women. https://doi.org/10.1289/EHP11814.

SUBMITTER: Zhan W

PROVIDER: S-EPMC10156134 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Publications

Environmental Exposure to Emerging Alternatives of Per- and Polyfluoroalkyl Substances and Polycystic Ovarian Syndrome in Women Diagnosed with Infertility: A Mixture Analysis.

Zhan Wenqiang W Qiu Wei W Ao Yan Y Zhou Wei W Sun Yun Y Zhao Han H Zhang Jun J

Environmental health perspectives 20230503 5

<h4>Background</h4>Per- and polyfluoroalkyl substances (PFAS) have been previously linked to polycystic ovarian syndrome (PCOS), but only a few legacy PFAS were examined.<h4>Objectives</h4>This study aimed to explore this association with a variety of PFAS, including legacy, branched-chain isomers, and emerging alternatives, as well as a PFAS mixture.<h4>Methods</h4>From 2014 to 2016, we conducted a multicenter, hospital-based case-control study on environmental endocrine disruptors and infertil ...[more]

PMID: 37134253

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Project description:The presence of per- and polyfluoroalkyl substances (PFASs) in the food chain poses a threat to human health. Water and the atmosphere are the major transport pathways for PFASs in the environment, while water, soil and sediment are sinks. Herein, the concentrations and distributions of traditional and emerging PFASs in multi-environmental media samples in the Qiantang River watershed were comprehensively investigated. Twenty-five PFASs, including seven emerging PFASs, were identified. The concentrations in water, soil, sediment and PM2.5 ranged from 3.58 to 786 ng L-1, 0.72 to 12.3 ng g-1, 0.73 to 6.60 ng g-1, and 93.9 to 255 pg m-3, respectively, with mean concentrations of 149 ng L-1, 4.70 ng g-1, 4.31 ng g-1, and 156 pg m-3. Perfluorooctanoic acid (PFOA) was the dominant contaminant in water, soil, and sediment, and perfluoropentanoic acid (PFPeA) was the dominant contaminant in PM2.5. Hexafluoropropylene oxide-dimer acid (HFPO-DA) and 6 : 2 chlorinated polyfluorinated ether sulfonate (6 : 2 Cl-PFESA), as substitutes for PFOA and perfluorooctane sulfonate (PFOS), were detected, indicating the gradual replacement of traditional PFOA and PFOS in this area. Perfluoro-3,6-dioxaheptanoic acid (NFDHA), as a component of the aqueous film-forming foam FN-3, was first detected in this area. Short-chain PFASs were mainly distributed in water and PM2.5, while long-chain PFASs were distributed in the solid phase, such as soil, sediment, and PM2.5. Based on principal component analysis (PCA), the major PFAS sources were emulsifiers from fluorine polymerization and surface-active agents from the textile, papermaking, leather, and other industries. In addition, correlation analysis showed that water was the main source and transport pathway of short-chain perfluoroalkyl carboxylic acid (PFCA), HFPO-DA, and NFDHA in this area, while the atmosphere combined with PM2.5 was the main transport pathway for both short- and long-chain PFCAs, PFOS, and 6 : 2 Cl-PFESA.

Project description:BackgroundOxidative stress from excess reactive oxygen species (ROS) is a hypothesized contributor to preterm birth. Per- and polyfluoroalkyl substances (PFAS) exposure is reported to generate ROS in laboratory settings, and is linked to adverse birth outcomes globally. However, to our knowledge, the relationship between PFAS and oxidative stress has not been examined in the context of human pregnancy.ObjectiveTo investigate the associations between prenatal PFAS exposure and oxidative stress biomarkers among pregnant people.MethodsOur analytic sample included 428 participants enrolled in the Illinois Kids Development Study and Chemicals In Our Bodies prospective birth cohorts between 2014 and 2019. Twelve PFAS were measured in second trimester serum. We focused on seven PFAS that were detected in >65 % of participants. Urinary levels of 8-isoprostane-prostaglandin-F2α, prostaglandin-F2α, 2,3-dinor-8-iso-PGF2α, and 2,3-dinor-5,6-dihydro-8-iso-PGF2α were measured in the second and third trimesters as biomarkers of oxidative stress. We fit linear mixed-effects models to estimate individual associations between PFAS and oxidative stress biomarkers. We used quantile g-computation and Bayesian kernel machine regression (BKMR) to assess associations between the PFAS mixture and averaged oxidative stress biomarkers.ResultsLinear mixed-effects models showed that an interquartile range increase in perfluorooctane sulfonic acid (PFOS) was associated with an increase in 8-isoprostane-prostaglandin-F2α (β = 0.10, 95 % confidence interval = 0, 0.20). In both quantile g-computation and BKMR, and across all oxidative stress biomarkers, PFOS contributed the most to the overall mixture effect. The six remaining PFAS were not significantly associated with changes in oxidative stress biomarkers.ConclusionsOur study is the first to investigate the relationship between PFAS exposure and biomarkers of oxidative stress during human pregnancy. We found that PFOS was associated with elevated levels of oxidative stress, which is consistent with prior work in animal models and cell lines. Future research is needed to understand how prenatal PFAS exposure and maternal oxidative stress may affect fetal development.

Dataset Information

Environmental Exposure to Emerging Alternatives of Per- and Polyfluoroalkyl Substances and Polycystic Ovarian Syndrome in Women Diagnosed with Infertility: A Mixture Analysis.

Background

Objectives

Methods

Results

Conclusions

Publications

Environmental Exposure to Emerging Alternatives of Per- and Polyfluoroalkyl Substances and Polycystic Ovarian Syndrome in Women Diagnosed with Infertility: A Mixture Analysis.

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