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Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers.

ABSTRACT: Crystallization of nicotine, an oil prone to degradation at room temperature, has been demonstrated to be an effective means of creating nicotine-based materials with tunable thermal properties and improved resistance to photo-induced degradation. Herein, we show that both isomers of enantiomerically pure tartaric acid are highly effective salt formers when combined with nicotine. Both salts exhibit enhanced photostability, and with a melting point of 143.1 °C, the salt prepared using d-(-)-tartaric acid possesses one of the highest melting points for a crystalline nicotine solid reported to date.

SUBMITTER: Angevine DJ

PROVIDER: S-EPMC10157684 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers.

Angevine Devin J DJ Camacho Kristine Joy KJ Zhang Xiaotong X Rzayev Javid J Benedict Jason B JB

ACS omega 20230418 17

Crystallization of nicotine, an oil prone to degradation at room temperature, has been demonstrated to be an effective means of creating nicotine-based materials with tunable thermal properties and improved resistance to photo-induced degradation. Herein, we show that both isomers of enantiomerically pure tartaric acid are highly effective salt formers when combined with nicotine. Both salts exhibit enhanced photostability, and with a melting point of 143.1 °C, the salt prepared using d-(-)-tart ...[more]

PMID: 37151519

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