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Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid.

ABSTRACT: The use of crystal engineering to convert liquids into crystalline solids remains a powerful method for inhibiting undesired degradation pathways. When nicotine, a liquid sensitive to both light and air, is combined with the GRAS-listed compound, gentisic acid, the resulting crystalline solid, exhibits enhanced photo and thermal stability. Despite a modest ΔT_m of 42.7 °C, the melting point of 155.9 °C for the nicotinium gentisate salt is the highest reported for nicotine-containing crystalline solids. An analysis of the crystal packing and thermodynamic properties provides context for the observed properties.

SUBMITTER: Angevine DJ

PROVIDER: S-EPMC9611154 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid.

Angevine Devin J DJ Camacho Kristine Joy KJ Rzayev Javid J Benedict Jason B JB

Molecules (Basel, Switzerland) 20221013 20

The use of crystal engineering to convert liquids into crystalline solids remains a powerful method for inhibiting undesired degradation pathways. When nicotine, a liquid sensitive to both light and air, is combined with the GRAS-listed compound, gentisic acid, the resulting crystalline solid, exhibits enhanced photo and thermal stability. Despite a modest ΔT<sub>m</sub> of 42.7 °C, the melting point of 155.9 °C for the nicotinium gentisate salt is the highest reported for nicotine-containing cr ...[more]

PMID: 36296448

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