Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid.

ABSTRACT: The use of crystal engineering to convert liquids into crystalline solids remains a powerful method for inhibiting undesired degradation pathways. When nicotine, a liquid sensitive to both light and air, is combined with the GRAS-listed compound, gentisic acid, the resulting crystalline solid, exhibits enhanced photo and thermal stability. Despite a modest ΔT_m of 42.7 °C, the melting point of 155.9 °C for the nicotinium gentisate salt is the highest reported for nicotine-containing crystalline solids. An analysis of the crystal packing and thermodynamic properties provides context for the observed properties.

SUBMITTER: Angevine DJ 

PROVIDER: S-EPMC9611154 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature