An arginase 2 promoter transgenic line illuminates immune cell polarisation in zebrafish.

ABSTRACT: Innate immune responses to inflammation and infection are complex and represent major challenges for developing much needed new treatments for chronic inflammatory diseases and drug-resistant infections. To be ultimately successful, the immune response must be balanced to allow pathogen clearance without excess tissue damage, processes controlled by pro- and anti-inflammatory signals. The roles of anti-inflammatory signalling in raising an appropriate immune response are underappreciated, representing overlooked potential drug targets. This is especially true in neutrophils, a difficult cell type to study ex vivo owing to a short lifespan, dogmatically seen as being highly pro-inflammatory. Here, we have generated and describe the first zebrafish transgenic line [TgBAC(arg2:eGFP)sh571] tha

SUBMITTER: Hammond FR 

PROVIDER: S-EPMC10163355 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature