Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE), a chronic allergic inflammatory disease, is linked to multiple genetic risk factors, but studies have focused on populations of European ancestry. Few studies have assessed Black or African American (AA) populations for loci involved in EoE susceptibility.

Objective

We performed admixture mapping (AM) and genome-wide association study (GWAS) of EoE using participants from AA populations.

Methods

We conducted AM and GWAS of EoE using 137 EoE cases and 1465 healthy controls from the AA population. Samples were genotyped using molecular evolutionary genetics analysis (MEGA). Genotype imputation was carried out with the Consortium on Asthma Among African-Ancestry Populations in the Americas (CAAPA) reference panel using the Michi

SUBMITTER: Gautam Y 

PROVIDER: S-EPMC10164699 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature