Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse.

ABSTRACT:

Objectives

The mid-palatal expansion technique is commonly used to correct maxillary constriction in dental clinics. However, there is a tendency for it to relapse, and the key molecules responsible for modulating bone formation remain elusive. Thus, this study aimed to investigate whether signal transducer and activator of transcription 3 (STAT3) activation contributes to osteoblast-mediated bone formation during palatal expansion and relapse.

Methodology

In total, 30 male Wistar rats were randomly allocated into Ctrl (control), E (expansion only), and E+Stattic (expansion plus STAT3-inhibitor, Stattic) groups. Micro-computed tomography, micromorphology staining, and immunohistochemistry of the mid-palatal suture were performed on days 7 and 14. In vitro cyclic tensile stre

SUBMITTER: Xiao X 

PROVIDER: S-EPMC10167947 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature