Tumor Necrosis Factor-α, CD1A and CD1E Genetic Polymorphisms in Guillain-Barre Syndrome: A Study from India.

ABSTRACT:

Background

Guillain-Barré Syndrome (GBS) is an acute acquired autoimmune inflammatory disorder of peripheral nerves and roots. The pathogenesis is essentially an aberrant post-infectious immune response in a genetically susceptible host milieu. Single nucleotide polymorphisms (SNP) in genes encoding the inflammatory mediators like TNF-α, CD1A and CD1E can influence their expression and level and the susceptibility and clinical course of disease in GBS.

Objective

We tried to study the susceptibility of single nucleotide polymorphisms of TNF-α and CD1 genes in Guillain-Barré Syndrome in Indian population and determine the association in terms of genotype, allele and haplotype distribution along with individual subtype, severity and clinical outcome.

Methodology

In this

SUBMITTER: Chakraborty R 

PROVIDER: S-EPMC10171006 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature