Porous Paclitaxel Mesh Reduces Local Recurrence in Patient-Derived Xenograft Resection Model.

ABSTRACT:

Background

Drug-loaded meshes offer a promising delivery strategy for the prevention of local recurrence. Patient-derived xenograft (PDX) models are representative of individual patient tumors and predictive of clinical outcomes.

Methods

A PDX model was established in NSG (NOD-scid IL2Rgamma^null) mice using tumor tissue from a patient with aggressive lung adenocarcinoma. Polyglycolic acid (PGA) meshes loaded with paclitaxel (PGA+PTX) were electrospun. Tumor-bearing mice were randomized into 4 groups after macroscopic complete resection: (1) no treatment (n = 10); (2) intraperitoneal PTX at 20 mg/kg (n = 10); (3) PGA mesh without drug (n = 14); and (4) PGA+PTX mesh at 12 mg/kg (n = 14). A 1-cm² mesh was placed onto the tumor resection beds. Groups were o

SUBMITTER: Tsai LL 

PROVIDER: S-EPMC10172394 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature