Ontology highlight
ABSTRACT:
SUBMITTER: Biswas U
PROVIDER: S-EPMC10172765 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Biswas Uddipta U Deb Mallik Tanaya T Pschirer Johannes J Lesche Matthias M Sameith Katrin K Jessberger Rolf R
Life science alliance 20230509 7
Previous data showed that meiotic cohesin SMC1β protects spermatocyte telomeres from damage. The underlying reason, however, remained unknown as the expressions of telomerase and shelterin components were normal in <i>Smc1</i>β <sup><i>-/-</i></sup> spermatocytes. Here. we report that SMC1β restricts expression of the long noncoding RNA TERRA (telomeric repeat containing RNA) in spermatocytes. In somatic cell lines increased TERRA was reported to cause telomere damage through altering telomere c ...[more]