The effect of weight loss following 18 months of lifestyle intervention on brain age assessed with resting-state functional connectivity.

ABSTRACT:

Background

Obesity negatively impacts multiple bodily systems, including the central nervous system. Retrospective studies that estimated chronological age from neuroimaging have found accelerated brain aging in obesity, but it is unclear how this estimation would be affected by weight loss following a lifestyle intervention.

Methods

In a sub-study of 102 participants of the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT-PLUS) trial, we tested the effect of weight loss following 18 months of lifestyle intervention on predicted brain age based on magnetic resonance imaging (MRI)-assessed resting-state functional connectivity (RSFC). We further examined how dynamics in multiple health factors, including anthropometric measurements, blood

SUBMITTER: Levakov G 

PROVIDER: S-EPMC10174688 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature