Changes in neural activity following a randomized trial of cognitive behavioral therapy for hoarding disorder.

ABSTRACT:

Objective

Cognitive behavioral therapy (CBT) is efficacious for hoarding disorder (HD), though results are modest. HD patients show an increase in activity in the dorsal anterior cingulate cortex (dACC) when making decisions. The aim of this study is to determine whether CBT's benefits follow improvements in dACC dysfunction or abnormalities previously identified in other brain regions.

Method

In this randomized clinical trial of 64 treatment-seeking HD patients, patients received group CBT, delivered weekly for 16 weeks, versus wait list. Functional magnetic resonance imaging was used to examine neural activity during simulated decisions about whether to acquire and discard objects.

Results

During acquiring decisions, activity decreased in several regions, including

SUBMITTER: Tolin DF 

PROVIDER: S-EPMC10175200 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature