Dual regulations of cell cycle regulator DPa by auxin in Arabidopsis root distal stem cell maintenance.

ABSTRACT: The plant hormone auxin plays a key role to maintain root stem cell identity which is essential for root development. However, the molecular mechanism by which auxin regulates root distal stem cell (DSC) identity is not well understood. In this study, we revealed that the cell cycle factor DPa is a vital regulator in the maintenance of root DSC identity through multiple auxin signaling cascades. On the one hand, auxin positively regulates the transcription of DPa via AUXIN RESPONSE FACTOR 7 and ARF19. On the other hand, auxin enhances the protein stability of DPa through MITOGEN-ACTIVATED PROTEIN KINASE 3 (MPK3)/MPK6-mediated phosphorylation. Consistently, mutation of the identified three threonine residues (Thr¹⁰, Thr²⁵, and Thr²²⁷) of DPa to nonpho

SUBMITTER: Wang J 

PROVIDER: S-EPMC10175748 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature