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Diabetes in HIV: the Link to Weight Gain.

ABSTRACT:

Purpose of review

The burden of metabolic diseases, including type 2 diabetes mellitus (T2DM), is rising among persons with HIV (PWH) on antiretroviral therapy (ART). This increase coincides with an aging population and a greater proportion who are overweight/obese. This review summarizes the changing epidemic of T2DM on contemporary ART, the role of weight gain, and therapeutic options.

Recent findings

Recent studies confirm that PWH face an epidemic of obesity and T2DM, similar to the general population. Contemporary ART is associated with greater weight gain and may contribute to the risk of T2DM. Recent advances in medical weight loss therapy offer a way forward in the prevention and treatment of weight-associated T2DM. Weight gain is one of the biggest contributors to T2DM in PWH. Future studies on the role of adipose tissue distribution, adipose tissue function and clinical use of effective weight loss medications may change the paradigm of care for PWH.

SUBMITTER: Bailin SS

PROVIDER: S-EPMC10184162 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Diabetes in HIV: the Link to Weight Gain.

Bailin Samuel S SS Koethe John R JR

Current HIV/AIDS reports 20221123 1

<h4>Purpose of review</h4>The burden of metabolic diseases, including type 2 diabetes mellitus (T2DM), is rising among persons with HIV (PWH) on antiretroviral therapy (ART). This increase coincides with an aging population and a greater proportion who are overweight/obese. This review summarizes the changing epidemic of T2DM on contemporary ART, the role of weight gain, and therapeutic options.<h4>Recent findings</h4>Recent studies confirm that PWH face an epidemic of obesity and T2DM, similar ...[more]

PMID: 36418528

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