PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity.

ABSTRACT:

Context

Metabolic disorders such as obesity represent a major health challenge. Obesity alone has reached epidemic proportions, with at least 2.8 million people worldwide dying annually from diseases caused by overweight or obesity. The brain-metabolic axis is central to maintain homeostasis under metabolic stress via an intricate signaling network of hormones. Protein interacting with C kinase 1 (PICK1) is important for the biogenesis of various secretory vesicles, and we have previously shown that PICK1-deficient mice have impaired secretion of insulin and growth hormone.

Objective

The aim was to investigate how global PICK1-deficient mice respond to high-fat diet (HFD) and assess its role in insulin secretion in diet-induced obesity.

Methods

We characterized the me

SUBMITTER: Backe MB 

PROVIDER: S-EPMC10185814 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature