Dataset Information

Exposure-response relationships for personal exposure to fine particulate matter (PM_2·5), carbon monoxide, and black carbon and birthweight: an observational analysis of the multicountry Household Air Pollution Intervention Network (HAPIN) trial.

ABSTRACT:

Background

Household air pollution (HAP) from solid fuel use is associated with adverse birth outcomes, but data for exposure-response relationships are scarce. We examined associations between HAP exposures and birthweight in rural Guatemala, India, Peru, and Rwanda during the Household Air Pollution Intervention Network (HAPIN) trial.

Methods

The HAPIN trial recruited pregnant women (9-<20 weeks of gestation) in rural Guatemala, India, Peru, and Rwanda and randomly allocated them to receive a liquefied petroleum gas stove or not (ie, and continue to use biomass fuel). The primary outcomes were birthweight, length-for-age, severe pneumonia, and maternal systolic blood pressure. In this exposure-response subanalysis, we measured 24-h personal exposures to PM_2·5, carbon monoxide, and black carbon once pre-intervention (baseline) and twice post-intervention (at 24-28 weeks and 32-36 weeks of gestation), as well as birthweight within 24 h of birth. We examined the relationship between the average prenatal exposure and birthweight or weight-for-gestational age Z scores using multivariate-regression models, controlling for the mother's age, nulliparity, diet diversity, food insecurity, BMI, the mother's education, neonate sex, haemoglobin, second-hand smoke, and geographical indicator for randomisation strata.

Findings

Between March, 2018, and February, 2020, 3200 pregnant women were recruited. An interquartile increase in the average prenatal exposure to PM_2·5 (74·5 μg/m³) was associated with a reduction in birthweight and gestational age Z scores (birthweight: -14·8 g [95% CI -28·7 to -0·8]; gestational age Z scores: -0·03 [-0·06 to 0·00]), as was an interquartile increase in black carbon (7·3 μg/m³; -21·9 g [-37·7 to -6·1]; -0·05 [-0·08 to -0·01]). Carbon monoxide exposure was not associated with these outcomes (1·7; -3·1 [-12·1 to 5·8]; -0·003 [-0·023 to 0·017]).

Interpretation

Continuing efforts are needed to reduce HAP exposure alongside other drivers of low birthweight in low-income and middle-income countries.

Funding

US National Institutes of Health (1UM1HL134590) and the Bill & Melinda Gates Foundation (OPP1131279).

SUBMITTER: Balakrishnan K

PROVIDER: S-EPMC10186177 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Publications

Exposure-response relationships for personal exposure to fine particulate matter (PM<sub>2·5</sub>), carbon monoxide, and black carbon and birthweight: an observational analysis of the multicountry Household Air Pollution Intervention Network (HAPIN) trial.

Balakrishnan Kalpana K Steenland Kyle K Clasen Thomas T Chang Howard H Johnson Michael M Pillarisetti Ajay A Ye Wenlu W Naeher Luke P LP Diaz-Artiga Anaite A McCracken John P JP Thompson Lisa M LM Rosa Ghislaine G Kirby Miles A MA Thangavel Gurusamy G Sambandam Sankar S Mukhopadhyay Krishnendu K Puttaswamy Naveen N Aravindalochanan Vigneswari V Garg Sarada S Ndagijimana Florien F Hartinger Stella S Underhill Lindsay J LJ Kearns Katherine A KA Campbell Devan D Kremer Jacob J Waller Lance L Jabbarzadeh Shirin S Wang Jiantong J Chen Yunyun Y Rosenthal Joshua J Quinn Ashlinn A Papageorghiou Aris T AT Ramakrishnan Usha U Howards Penelope P PP Checkley William W Peel Jennifer L JL

The Lancet. Planetary health 20230501 5

<h4>Background</h4>Household air pollution (HAP) from solid fuel use is associated with adverse birth outcomes, but data for exposure-response relationships are scarce. We examined associations between HAP exposures and birthweight in rural Guatemala, India, Peru, and Rwanda during the Household Air Pollution Intervention Network (HAPIN) trial.<h4>Methods</h4>The HAPIN trial recruited pregnant women (9-<20 weeks of gestation) in rural Guatemala, India, Peru, and Rwanda and randomly allocated the ...[more]

PMID: 37164515

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Dataset Information

Exposure-response relationships for personal exposure to fine particulate matter (PM_2·5), carbon monoxide, and black carbon and birthweight: an observational analysis of the multicountry Household Air Pollution Intervention Network (HAPIN) trial.

Background

Methods

Findings

Interpretation

Funding

Publications

Exposure-response relationships for personal exposure to fine particulate matter (PM<sub>2·5</sub>), carbon monoxide, and black carbon and birthweight: an observational analysis of the multicountry Household Air Pollution Intervention Network (HAPIN) trial.

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Tweets

Dataset Information

Exposure-response relationships for personal exposure to fine particulate matter (PM2·5), carbon monoxide, and black carbon and birthweight: an observational analysis of the multicountry Household Air Pollution Intervention Network (HAPIN) trial.

Background

Methods

Findings

Interpretation

Funding

Publications

Exposure-response relationships for personal exposure to fine particulate matter (PM<sub>2·5</sub>), carbon monoxide, and black carbon and birthweight: an observational analysis of the multicountry Household Air Pollution Intervention Network (HAPIN) trial.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Exposure-response relationships for personal exposure to fine particulate matter (PM_2·5), carbon monoxide, and black carbon and birthweight: an observational analysis of the multicountry Household Air Pollution Intervention Network (HAPIN) trial.