Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1.

ABSTRACT: Psychological stress increases the susceptibility to herpes simplex virus type 1 (HSV-1) infection. There is no effective intervention due to the unknown pathogenesis mechanisms. In this study we explored the molecular mechanisms underlying stress-induced HSV-1 susceptibility and the antiviral effect of a natural compound rosmarinic acid (RA) in vivo and in vitro. Mice were administered RA (11.7, 23.4 mg·kg^-1·d^-1, i.g.) or acyclovir (ACV, 206 mg·kg^-1·d^-1, i.g.) for 23 days. The mice were subjected to restraint stress for 7 days followed by intranasal infection with HSV-1 on D7. At the end of RA or ACV treatment, mouse plasma samples and brain tissues were collected for analysis. We showed that both RA and ACV treatment significantly decreased str

SUBMITTER: Weng JY 

PROVIDER: S-EPMC10186316 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature