The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting.

ABSTRACT:

Introduction

In contrast to other breast cancer subtypes, there are currently limited options of targeted therapies for triple-negative breast cancer (TNBC). Immense research has demonstrated that not only cancer cells but also stromal cells and immune cells in the tumor microenvironment (TME) play significant roles in the progression of TNBC. It is thus critical to understand the components of the TME of TNBC and the interactions between the various cell populations.

Areas covered

The components of the TME of TNBC identified by single-cell technologies are reviewed. Furthermore, the molecular interactions between the cells and the potential therapeutic targets contributing to the progression of TNBC are discussed.

Expert opinion

Single-cell omics studies have contrib

SUBMITTER: Furukawa N 

PROVIDER: S-EPMC10189896 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature