Identification of an anergic BND cell-derived activated B cell population (BND2) in young-onset type 1 diabetes patients.

ABSTRACT: Recent evidence suggests a role for B cells in the pathogenesis of young-onset type 1 diabetes (T1D), wherein rapid progression occurs. However, little is known regarding the specificity, phenotype, and function of B cells in young-onset T1D. We performed a cross-sectional analysis comparing insulin-reactive to tetanus-reactive B cells in the blood of T1D and controls using mass cytometry. Unsupervised clustering revealed the existence of a highly activated B cell subset we term BND2 that falls within the previously defined anergic BND subset. We found a specific increase in the frequency of insulin-reactive BND2 cells in the blood of young-onset T1D donors, which was further enriched in the pancreatic lymph nodes of T1D donors. The frequency of insulin-binding BND2 cells correlated with a

SUBMITTER: Stensland ZC 

PROVIDER: S-EPMC10192302 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature