A riboswitch-controlled manganese exporter (Alx) tunes intracellular Mn ²⁺ concentration in E. coli at alkaline pH.

ABSTRACT: Cells use transition metal ions as structural components of biomolecules and cofactors in enzymatic reactions, making transition metals vital cellular components. The buildup of a particular metal ion in certain stress conditions becomes harmful to the organism due to the misincorporation of the excess ion into biomolecules, resulting in perturbed enzymatic activity or metal-catalyzed formation of reactive oxygen species. Organisms optimize metal concentration by regulating the expression of proteins that import and export that metal, often in a metal concentration-dependent manner. One such regulation mechanism is via riboswitches, which are 5'-untranslated regions (UTR) of an mRNA that undergo conformational changes to promote or inhibit the expression of the downstream gene, commonly in

SUBMITTER: Sharma R 

PROVIDER: S-EPMC10197570 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature