Regulatory T Cells Require CCR6 for Skin Migration and Local Suppression of Vitiligo.

ABSTRACT: Vitiligo is an autoimmune skin disease caused by melanocyte-targeting autoreactive CD8+ T cells. Regulatory T cells (Tregs) have been implicated in restraining vitiligo severity in both mouse models and human patients; however, whether they must be present in the skin for their suppressive function is still unclear. We observed uneven distribution of Tregs within different anatomical locations of mouse skin, which correlated with reduced depigmentation after vitiligo induction. We specifically depleted Tregs in our mouse model of vitiligo and observed increased disease. Next, we found that Tregs contact CD8+ T effector cells in vitiligo lesional skin and that Treg recruitment to the skin inversely correlated with disease severity, suggesting a critical role for Treg suppression within the

SUBMITTER: Essien KI 

PROVIDER: S-EPMC10198248 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature