Ontology highlight
ABSTRACT:
SUBMITTER: Tomiyama T
PROVIDER: S-EPMC3767606 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Tomiyama Takashi T Ueda Yoshihiro Y Katakai Tomoya T Kondo Naoyuki N Okazaki Kazuichi K Kinashi Tatsuo T
PloS one 20130909 9
Although the cell-to-cell contact between CD4(+)Foxp3(+) regulatory T (Treg) and their target cells is important for the suppressor function of Treg cells, the regulation of this process is not well understood. Here we show that the Mst1 kinase plays a critical role in the suppressor function of Treg cells through regulation of cell contact dependent processes. Mst1 (-/-) Treg cells failed to prevent the development of experimental colitis and antigen-specific suppression of naïve T cells prolif ...[more]