Immunological synapse arrays: patterned protein surfaces that modulate immunological synapse structure formation in T cells.

ABSTRACT: T cells are activated by recognition of foreign peptides displayed on the surface of antigen presenting cells (APCs), an event that triggers assembly of a complex microscale structure at the T cell-APC interface known as the immunological synapse (IS). It remains unresolved whether the unique physical structure of the synapse itself impacts the functional response of T cells, independent of the quantity and quality of ligands encountered by the T cell. As a first step toward addressing this question, we created multicomponent protein surfaces presenting lithographically defined patterns of tethered T cell receptor (TCR) ligands (anti-CD3 "activation sites") surrounded by a field of tethered intercellular adhesion molecule-1 (ICAM-1), as a model substrate on which T cells could be seeded to

SUBMITTER: Doh J 

PROVIDER: S-EPMC1458636 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature