Dataset Information

Central retina plays a decisive role in the suppression of pupillary escape.

ABSTRACT:

Purpose

To explore the pupil redilation during persistent light exposure (pupillary escape phenomenon) at the macula and periphery with monochromatic light stimuli.

Methods

Forty healthy subjects aged 18-64 years (24 females) were examined by chromatic pupil campimetry (CPC) using red and blue 4-s stimuli of 10° radius at the center and 20°-peripheral locations one per quadrant. One glaucoma patient and one achromatopsia patient served as disease models. For statistical analyses, linear mixed-effects models were performed followed by post hoc t-tests.

Results

A distinct pupillary escape could be demonstrated peripherally (blue 0.099%*s, red 0.153%*s); at the central healthy retina, there was no relevant escape, neither for blue nor red stimulation. Comparing central versus peripheral stimulation revealed highly significant differences in the escape (difference blue 0.100 ± 0.013, red 0.144 ± 0.013, < 0.0001, respectively). In the periphery, the escape was significantly more pronounced for red compared with blue stimulation (difference 0.054 ± 0.013; p = 0.0001). Enhanced pupillary escape outside of the 95% confidence interval of the linear mixed-effects model of the healthy population could be exemplarily shown in a patient with glaucomatous ganglion cell damage. In the achromatopsia example, no relevant escape was found for blue stimulation, but for red stimulation in the periphery in a comparable range to healthy controls.

Conclusion

The results emphasize that an intact inner retinal network of nerve fibers arising from the central macular region is necessary for maintaining pupillary constriction during a bright 4-s light stimulus and preventing increase of pupillary escape. Increasing receptive field sizes towards the periphery on the level of retinal ganglion cells and less input from central 1:1 connections could be one of the driving mechanisms for pupillary escape.

SUBMITTER: Kelbsch C

PROVIDER: S-EPMC10199107 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Publications

Central retina plays a decisive role in the suppression of pupillary escape.

Kelbsch Carina C Jendritza Ricarda R Strasser Torsten T Tonagel Felix F Richter Paul P Jung Ronja R Peters Tobias T Wilhelm Helmut H Wilhelm Barbara B Stingl Krunoslav K

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20230116 6

<h4>Purpose</h4>To explore the pupil redilation during persistent light exposure (pupillary escape phenomenon) at the macula and periphery with monochromatic light stimuli.<h4>Methods</h4>Forty healthy subjects aged 18-64 years (24 females) were examined by chromatic pupil campimetry (CPC) using red and blue 4-s stimuli of 10° radius at the center and 20°-peripheral locations one per quadrant. One glaucoma patient and one achromatopsia patient served as disease models. For statistical analyses, ...[more]

PMID: 36645454

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Dataset Information

Central retina plays a decisive role in the suppression of pupillary escape.

Purpose

Methods

Results

Conclusion

Publications

Central retina plays a decisive role in the suppression of pupillary escape.

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