Dataset Information

Hypertensive disorders of pregnancy and subsequent risk of Alzheimer's disease and other dementias.

ABSTRACT:

Introduction

Women with hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular disease. Whether HDP is also associated with later-life dementia has not been fully explored.

Methods

Using the Utah Population Database, we performed an 80-year retrospective cohort study of 59,668 parous women.

Results

Women with, versus without, HDP, had a 1.37 higher risk of all-cause dementia (95% confidence interval [CI]: 1.26, 1.50) after adjustment for maternal age at index birth, birth year, and parity. HDP was associated with a 1.64 higher risk of vascular dementia (95% CI: 1.19, 2.26) and 1.49 higher risk of other dementia (95% CI: 1.34, 1.65) but not Alzheimer's disease dementia (adjusted hazard ratio = 1.04; 95% CI: 0.87, 1.24). Gestational hypertension and preeclampsia/eclampsia showed similar increased dementia risk. Nine mid-life cardiometabolic and mental health conditions explained 61% of HDP's effect on subsequent dementia risk.

Discussion

Improved HDP and mid-life care could reduce the risk of dementia.

SUBMITTER: Schliep KC

PROVIDER: S-EPMC10201212 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature

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Publications

Hypertensive disorders of pregnancy and subsequent risk of Alzheimer's disease and other dementias.

Schliep Karen C KC Shaaban C Elizabeth CE Meeks Huong H Fraser Alison A Smith Ken R KR Majersik Jennifer J JJ Foster Norman L NL Wactawski-Wende Jean J Østbye Truls T Tschanz JoAnn J Padbury James F JF Sharma Surrendra S Zhang Yue Y Facelli Julio C JC Abdelrahman C Samir CS Theilen Lauren L Varner Michael W MW

Alzheimer's & dementia (Amsterdam, Netherlands) 20230401 2

<h4>Introduction</h4>Women with hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular disease. Whether HDP is also associated with later-life dementia has not been fully explored.<h4>Methods</h4>Using the Utah Population Database, we performed an 80-year retrospective cohort study of 59,668 parous women.<h4>Results</h4>Women with, versus without, HDP, had a 1.37 higher risk of all-cause dementia (95% confidence interval [CI]: 1.26, 1.50) after adjustment for maternal ...[more]

PMID: 37223334

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Dataset Information

Hypertensive disorders of pregnancy and subsequent risk of Alzheimer's disease and other dementias.

Introduction

Methods

Results

Discussion

Publications

Hypertensive disorders of pregnancy and subsequent risk of Alzheimer's disease and other dementias.

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