GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.

ABSTRACT: Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown¹ to be highly efficient for discovery of genetic associations². Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group³. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases)

SUBMITTER: Pairo-Castineira E 

PROVIDER: S-EPMC10208981 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature