A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation.

ABSTRACT:

Background

Acetaminophen (APAP) is the most common cause liver injury following alcohol in US patients. Predicting liver injury and subsequent hepatic regeneration in patients taking therapeutic doses of APAP may be possible using new 'omic methods such as metabolomics and genomics. Multi'omic techniques increase our ability to find new mechanisms of injury and regeneration.

Methods

We used metabolomic and genomic data from a randomized controlled trial of patients administered 4 g of APAP per day for 14 days or longer with blood samples obtained at 0 (baseline), 4, 7, 10, 13 and 16 days. We used the highest ALT as the clinical outcome to be predicted in our integrated analysis. We used penalized regression to model the relationship between genetic variants and day 0 metabol

SUBMITTER: Monte AA 

PROVIDER: S-EPMC10212224 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature