Biomarkers detected in cord blood predict vaccine responses in young infants.

ABSTRACT:

Introduction

Factors influencing vaccine immune priming in the first year of life involve both innate and adaptive immunity but there are gaps in understanding how these factors sustain vaccine antibody levels in healthy infants. The hypothesis was that bioprofiles associated with B cell survival best predict sustained vaccine IgG levels at one year.

Methods

Longitudinal study of plasma bioprofiles in 82 term, healthy infants, who received standard recommended immunizations in the United States, with changes in 15 plasma biomarker concentrations and B cell subsets associated with germinal center development monitored at birth, soon after completion of the initial vaccine series at 6 months, and prior to the 12-month vaccinations. Post vaccination antibody IgG levels to Bo

SUBMITTER: Baloh CH 

PROVIDER: S-EPMC10213698 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature