Derivation and comparison of formulae for the adjustment of total calcium.

ABSTRACT:

Background

Free ionized calcium (Ca²⁺) is the biologically active component of total calcium (TCa) and hence responsible for its biological action. TCa is routinely adjusted for albumin using several formulae (e.g. James, Orell, Payne and Berry) to more closely reflect Ca²⁺. Here, we derive a novel formula to estimate Ca²⁺ and compare its performance to established formulae.

Methods

Cohort for prediction of Ca²⁺: 2806 serum samples (TCa) taken contemporaneously with blood gas samples (Ca²⁺) at Imperial College Healthcare NHS Trust were used to derive formulae to estimate Ca²⁺ using multivariable linear regression. Cohort for prediction of PTH: Performance of novel and existing formulae to predict

SUBMITTER: Phylactou M 

PROVIDER: S-EPMC10213740 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature