Prophylactic cranial irradiation-related lymphopenia affects survival in patients with limited-stage small cell lung cancer.

ABSTRACT:

Background

The study aimed to identify the relations of the absolute lymphocyte count (ALC) nadir during prophylactic cranial irradiation (PCI) and patient outcomes in limited-stage small cell lung cancer (LS-SCLC).

Methods

We analyzed 268 L S-SCLC patients who underwent PCI from 2012 to 2019. ALC values were collected prior, during, and 3 months post PCI. Kaplan-Meier and Cox regression analyses were performed to assess the relation of ALC to patient prognosis. Two nomograms were developed on the basis of clinical variables for survival prediction.

Results

Compared with the ALC before PCI (1.13 × 10⁹ cells/L), the ALC nadir during PCI was significantly reduced by 0.68 × 10⁹ cells/L (P < 0.001) and raised to 1.02 × 10⁹ cells/L 3 months

SUBMITTER: Fan X 

PROVIDER: S-EPMC10220366 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature