Emergence of a Hybrid IncI1-Iα Plasmid-Encoded bla_CTX-M-101 Conferring Resistance to Cephalosporins in Salmonella enterica Serovar Enteritidis.

ABSTRACT: The increasing resistance to cephalosporins in Salmonella poses a serious threat to public health. In our previous study, the bla_CTX-M-101 gene, a new bla_CTX-M variant, was first reported in Salmonella enterica serovar Enteritidis (S. Enteritidis). Here, we further analyzed the genome characterization, transferability, and resistance mechanism of one S. Enteritidis isolate (SJTUF14523) carrying bla_CTX-M-101 from an outpatient in 2016 in Xinjiang, China. This strain was a multidrug resistance (MDR) isolate and exhibited resistance to ceftazidime (MIC = 64 μg/mL), cefotaxime (MIC = 256 μg/mL), and cefepime (MIC = 16 μg/mL). Phylogenetic analysis revealed that SJTUF14523 had a close relationship to another S.

SUBMITTER: Qin X 

PROVIDER: S-EPMC10222410 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature