CD169⁺ sinus macrophages in regional lymph nodes do not predict mismatch-repair status of patients with colorectal cancer.

ABSTRACT:

Aims

Mismatch-repair deficiency and microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC) is treated with programmed death (PD)-1 antibody regardless of PD-ligand (L)1 expression in tumor cells. We previously found that abundant CD169⁺ macrophages in regional lymph node (RLN) sinuses and CD8⁺ tumor-infiltrating lymphocytes (TILs) positively correlated in CRC and were associated with a favorable prognosis. However, associations between dMMR/MSI-H CRC and CD8⁺ TILs or prognoses vary among studies. In this study, we attempted to compare the association between MMR status, CD169⁺ macrophages in RLNs, CD8⁺ TILs, PD-L1 scores, and prognoses in CRC.

Methods and results

We immunostained 83 surgically resected CRC

SUBMITTER: Saito Y 

PROVIDER: S-EPMC10225197 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature