Platelet versus plasma CXCL14, coronary artery disease, and clinical outcomes.

ABSTRACT:

Background

Platelets express CXCL14, while platelet-derived CXCL14 induces monocyte chemotaxis and exerts an angiostatic effect on endothelial cells.

Objectives

This study investigated both platelet surface-associated and circulating levels of CXCL14 in patients with heart disease and associations of this chemokine with myocardial function and outcomes in patients with coronary artery disease (CAD).

Methods

This prospective study enrolled 450 patients with symptomatic heart disease. Platelet surface-associated and plasma CXCL14 levels were analyzed. All patients were followed up for 360 days for a primary composite outcome consisting of all-cause mortality, myocardial infarction, and/or ischemic stroke. Secondary outcomes consisted of the single events of all-cause mo

SUBMITTER: Schories C 

PROVIDER: S-EPMC10225916 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature