Dataset Information

Platelet versus plasma CXCL14, coronary artery disease, and clinical outcomes.

ABSTRACT:

Background

Platelets express CXCL14, while platelet-derived CXCL14 induces monocyte chemotaxis and exerts an angiostatic effect on endothelial cells.

Objectives

This study investigated both platelet surface-associated and circulating levels of CXCL14 in patients with heart disease and associations of this chemokine with myocardial function and outcomes in patients with coronary artery disease (CAD).

Methods

This prospective study enrolled 450 patients with symptomatic heart disease. Platelet surface-associated and plasma CXCL14 levels were analyzed. All patients were followed up for 360 days for a primary composite outcome consisting of all-cause mortality, myocardial infarction, and/or ischemic stroke. Secondary outcomes consisted of the single events of all-cause mortality or myocardial infarction.

Results

Baseline platelet-associated but not circulating CXCL14 levels were significantly lower in patients with chronic coronary syndrome (mean fluorescence intensity logarithmized, 1.35 ± 0.35) when compared to those with acute coronary syndrome (1.47 ± 0.38) and without CAD (1.51 ± 0.40). Platelet CXCL14 levels were significantly lower (1.37 ± 0.37 vs 1.48 ± 0.39) and circulating CXCL14 levels were significantly higher (lg, 2.88 ± 0.20 pg/mL vs 2.82 ± 0.26 pg/mL) in patients with normal baseline left ventricular ejection fraction (LVEF) when compared to those with impaired LVEF. Low baseline circulating CXCL14 (hazard ratio, 2.33; 1.00-5.46) but not platelet CXCL14 was associated with worse outcome in patients with CAD.

Conclusion

Platelet-associated and circulating CXCL14 levels show differential regulation in patients with and without CAD. Although platelet-associated CXCL14 increased and circulating CXCL14 decreased with impairment of LVEF, only lower circulating CXCL14 upon admission was associated with worse prognosis in patients with CAD.

SUBMITTER: Schories C

PROVIDER: S-EPMC10225916 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Publications

Platelet versus plasma CXCL14, coronary artery disease, and clinical outcomes.

Schories Christoph C Martus Peter P Guan Tianyun T Henes Jessica Kristin JK Witte Alexander A Müller Karin K Geisler Tobias T Chatterjee Madhumita M Gawaz Meinrad M Rath Dominik D

Research and practice in thrombosis and haemostasis 20230425 4

<h4>Background</h4>Platelets express CXCL14, while platelet-derived CXCL14 induces monocyte chemotaxis and exerts an angiostatic effect on endothelial cells.<h4>Objectives</h4>This study investigated both platelet surface-associated and circulating levels of CXCL14 in patients with heart disease and associations of this chemokine with myocardial function and outcomes in patients with coronary artery disease (CAD).<h4>Methods</h4>This prospective study enrolled 450 patients with symptomatic heart ...[more]

PMID: 37255851

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Dataset Information

Platelet versus plasma CXCL14, coronary artery disease, and clinical outcomes.

Background

Objectives

Methods

Results

Conclusion

Publications

Platelet versus plasma CXCL14, coronary artery disease, and clinical outcomes.

Similar Datasets

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