Hydrazone Molecular Switches with Paramagnetic Center as ¹⁹F Magnetic Resonance Imaging Relaxation Enhancement Agents for pH Imaging.

ABSTRACT: The design and synthesis of hydrazone-based switches with a CF₃ reporting group for ¹⁹F pH imaging using relaxation rate changes were described. A paramagnetic center was introduced into the hydrazone molecular switch scaffold by substitution of an ethyl functional group with a paramagnetic complex. The mechanism of activation relies on a gradual increase in T₁ and T₂ magnetic resonance imaging (MRI) relaxation times as pH decreases due to E/Z isomerization, which results in a change in the distance between fluorine atoms and the paramagnetic center. Among the three possible variants of the ligand, the meta isomer was found to offer the highest potential changes in relaxation rates due to the significant paramagnetic r

SUBMITTER: Janasik D 

PROVIDER: S-EPMC10226166 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature