A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles.

ABSTRACT: Nucleic acid therapeutics require delivery systems to reach their targets. Key challenges to be overcome include avoidance of accumulation in cells of the mononuclear phagocyte system and escape from the endosomal pathway. Spherical nucleic acids (SNAs), in which a gold nanoparticle supports a corona of oligonucleotides, are promising carriers for nucleic acids with valuable properties including nuclease resistance, sequence-specific loading and control of receptor-mediated endocytosis. However, SNAs accumulate in the endosomal pathway and are thus vulnerable to lysosomal degradation or recycling exocytosis. Here, an alternative SNA core based on diblock copolymer PMPC₂₅-PDPA₇₂ is investigated. This pH-sensitive polymer self-assembles into vesicles with an intrinsic a

SUBMITTER: Garcia-Guerra A 

PROVIDER: S-EPMC10228346 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature