Association between diesel exhaust exposure and mitochondrial DNA methylation.

ABSTRACT:

Objectives

Diesel exhaust is an established human carcinogen, however the mechanisms by which it leads to cancer development are not fully understood. Mitochondrial dysfunction is an established contributor to carcinogenesis. Recent studies have improved our understanding of the role played by epigenetic modifications in the mitochondrial genome on tumorigenesis. In this study, we aim to evaluate the association between diesel engine exhaust (DEE) exposure with mitochondrial DNA (mtDNA) methylation levels in workers exposed to DEE.

Methods

The study population consisted of 53 male workers employed at a diesel engine manufacturing facility in Northern China who were routinely exposed to diesel exhaust in their occupational setting, as well as 55 unexposed male control workers

SUBMITTER: Seow WJ 

PROVIDER: S-EPMC10233238 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature