Dataset Information

Impacts of long-term ambient particulate matter and gaseous pollutants on circulating biomarkers of inflammation in male and female health professionals.

ABSTRACT:

Background

Systemic inflammation may serve as a biological mechanism linking air pollution to poor health but supporting evidence from studies of long-term pollutant exposure and inflammatory cytokines is inconsistent.

Objective

We studied associations between multiple particulate matter (PM) and gaseous air pollutants and pro- and anti-inflammatory cytokines within two nationwide cohorts of men and women.

Methods

Data were obtained from 16,151 women in the Nurses' Health Study and 7,930 men in the Health Professionals' Follow-up Study with at least one measure of circulating adiponectin, C-Reactive Protein (CRP), Interleukin-6 (IL-6) or soluble tumor necrosis-factor receptor-2 (sTNFR-2). Exposure to PM with aerodynamic diameter ≤2.5, 2.5-10, and ≤10 μm (PM_2.5, PM_2.5-₁₀, PM₁₀) and nitrogen dioxide (NO₂) was estimated using spatio-temporal models and were linked to participants' addresses at the time of blood draw. Averages of the 1-, 3-, and 12-months prior to blood draw were examined. Associations between each biomarker and pollutant were estimated from linear regression models adjusted for individual and contextual covariates.

Results

In adjusted models, we observed a 2.72% (95% CI: 0.43%, 5.95%), 3.11% (-0.12%, 6.45%), and 3.67% (0.19%, 7.26%) increase in CRP associated with a 10 μg/m³ increase in 1-, 3-, and 12- month averaged NO₂ in women. Among men, there was a statistically significant 5.96% (95% CI: 0.07%, 12.20%), 6.99% (95% CI: 0.29%, 14.15%), and 8.33% (95% CI: 0.35%, 16.94%) increase in CRP associated with a 10 μg/m³ increase in 1-, 3-, and 12-month averaged PM_2.5-10, respectively. Increasing PM_2.5-10 was associated with increasing IL-6 and sTNFR-2 among men over shorter exposure durations. There were no associations with exposures to PM_2.5 or PM₁₀, or with adiponectin. Findings were robust to sensitivity analyses restricting to disease-free controls and non-movers.

Conclusions

Across multiple long-term pollutant exposures and inflammatory markers, associations were generally weak. Focusing on specific pollutant-inflammatory mechanisms may clarify pathways.

SUBMITTER: Iyer HS

PROVIDER: S-EPMC10234694 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Impacts of long-term ambient particulate matter and gaseous pollutants on circulating biomarkers of inflammation in male and female health professionals.

Iyer Hari S HS Hart Jaime E JE Fiffer Melissa R MR Elliott Elise G EG Yanosky Jeff D JD Kaufman Joel D JD Puett Robin C RC Laden Francine F

Environmental research 20220704 Pt 1

<h4>Background</h4>Systemic inflammation may serve as a biological mechanism linking air pollution to poor health but supporting evidence from studies of long-term pollutant exposure and inflammatory cytokines is inconsistent.<h4>Objective</h4>We studied associations between multiple particulate matter (PM) and gaseous air pollutants and pro- and anti-inflammatory cytokines within two nationwide cohorts of men and women.<h4>Methods</h4>Data were obtained from 16,151 women in the Nurses' Health S ...[more]

PMID: 35798268

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Dataset Information

Impacts of long-term ambient particulate matter and gaseous pollutants on circulating biomarkers of inflammation in male and female health professionals.

Background

Objective

Methods

Results

Conclusions

Publications

Impacts of long-term ambient particulate matter and gaseous pollutants on circulating biomarkers of inflammation in male and female health professionals.

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