ACDC: a general approach for detecting phenotype or exposure associated co-expression.

ABSTRACT:

Background

Existing module-based differential co-expression methods identify differences in gene-gene relationships across phenotype or exposure structures by testing for consistent changes in transcription abundance. Current methods only allow for assessment of co-expression variation across a singular, binary or categorical exposure or phenotype, limiting the information that can be obtained from these analyses.

Methods

Here, we propose a novel approach for detection of differential co-expression that simultaneously accommodates multiple phenotypes or exposures with binary, ordinal, or continuous data types.

Results

We report an application to two cohorts of asthmatic patients with varying levels of asthma control to identify associations between gene co-expression

SUBMITTER: Queen K 

PROVIDER: S-EPMC10235619 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature